Which organism produces a grayish-white pseudomembrane in the oropharynx?

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Prepare for the NBME Microbiology Test. Study with flashcards and multiple-choice questions. Each query comes with hints and detailed explanations. Ace your exam!

Multiple Choice

Which organism produces a grayish-white pseudomembrane in the oropharynx?

Explanation:
Grayish-white pseudomembrane in the oropharynx is a hallmark of diphtheria caused by Corynebacterium diphtheriae. This organism can produce an exotoxin that inactivates elongation factor-2, halting host protein synthesis. The resulting necrosis plus fibrin-rich exudate forms a tough, adherent membrane on the pharyngeal and tonsillar mucosa, which can bleed if scraped and may obstruct the airway in severe cases. Vaccination with diphtheria toxoid prevents this disease. Other throat pathogens may cause exudative tonsillitis, but they do not produce this characteristic pseudomembrane.

Grayish-white pseudomembrane in the oropharynx is a hallmark of diphtheria caused by Corynebacterium diphtheriae. This organism can produce an exotoxin that inactivates elongation factor-2, halting host protein synthesis. The resulting necrosis plus fibrin-rich exudate forms a tough, adherent membrane on the pharyngeal and tonsillar mucosa, which can bleed if scraped and may obstruct the airway in severe cases. Vaccination with diphtheria toxoid prevents this disease. Other throat pathogens may cause exudative tonsillitis, but they do not produce this characteristic pseudomembrane.

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