The HIV env gene encodes envelope proteins that are cleaved into which mature products?

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Prepare for the NBME Microbiology Test. Study with flashcards and multiple-choice questions. Each query comes with hints and detailed explanations. Ace your exam!

Multiple Choice

The HIV env gene encodes envelope proteins that are cleaved into which mature products?

Explanation:
HIV envelope proteins are made as a single gp160 precursor that is cleaved by host proteases in the secretory pathway. This cleavage yields two mature subunits: gp120, the external subunit that binds CD4 (and a coreceptor), and gp41, the transmembrane subunit that anchors the spike and mediates membrane fusion. In the mature virion, gp120 and gp41 stay together as a functional gp120/gp41 complex. So the mature products are gp120 and gp41.

HIV envelope proteins are made as a single gp160 precursor that is cleaved by host proteases in the secretory pathway. This cleavage yields two mature subunits: gp120, the external subunit that binds CD4 (and a coreceptor), and gp41, the transmembrane subunit that anchors the spike and mediates membrane fusion. In the mature virion, gp120 and gp41 stay together as a functional gp120/gp41 complex. So the mature products are gp120 and gp41.

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