HTLV-1 is a retrovirus associated with which malignancy?

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Prepare for the NBME Microbiology Test. Study with flashcards and multiple-choice questions. Each query comes with hints and detailed explanations. Ace your exam!

Multiple Choice

HTLV-1 is a retrovirus associated with which malignancy?

Explanation:
HTLV-1 is a retrovirus that is best connected with adult T-cell leukemia/lymphoma. Infection by HTLV-1 can drive malignant transformation of CD4+ T cells, largely through the Tax oncoprotein which promotes cell growth and survival and disrupts normal cellular controls. This makes ATLL the classic malignancy associated with HTLV-1. The other options point to diseases caused by different viruses or to non-viral conditions—hairy cell leukemia is a mature B-cell neoplasm not linked to a virus; Burkitt lymphoma is strongly associated with EBV; Kaposi sarcoma is linked to HHV-8.

HTLV-1 is a retrovirus that is best connected with adult T-cell leukemia/lymphoma. Infection by HTLV-1 can drive malignant transformation of CD4+ T cells, largely through the Tax oncoprotein which promotes cell growth and survival and disrupts normal cellular controls. This makes ATLL the classic malignancy associated with HTLV-1. The other options point to diseases caused by different viruses or to non-viral conditions—hairy cell leukemia is a mature B-cell neoplasm not linked to a virus; Burkitt lymphoma is strongly associated with EBV; Kaposi sarcoma is linked to HHV-8.

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